How Much DNA Do Grandparents Share With Their Grandchildren

Have you ever wondered just how much of your DNA you inherited from your grandparents? Do females get more from their grandmothers? Do males get more from their grandfathers?

While most of us are familiar with the genetic traits passed down from parents, the extent of genetic influence from grandparents is often overlooked. Your genetic makeup comes from a blend of all four of your biological grandparents.

I encounter numerous DNA companies claiming that individuals inherit exactly 25% of their DNA from each grandparent. However, it’s improbable for someone to receive precisely the same amount of DNA from each grandparent. I chose to put the theory to the test by undergoing DNA testing along with my sister, our maternal grandmother and both paternal grandparents. The outcomes deviated from the anticipated exact 25% suggested by other companies.

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How DNA is Passed Along

Understanding how DNA is passed along is crucial. Illustrated in the chart below, it is clear that the individual how dna passinherits 50% of their autosomal DNA from their mother and 50% from their father. Autosomal markers typically carry 2 alleles, with one allele inherited from the father and the other from the mother, resulting in equal contributions from each parent.

Consequently, the combined genetic contribution of maternal grandparents constitutes 50% of a person’s DNA. However, the specific portion of DNA inherited from the maternal grandmother versus the maternal grandfather is entirely random. Likewise, the principle applies to paternal grandparents.

Genetic recombination is the process responsible for the random assortment of DNA segments from each grandparent. This is where chromosomes undergo shuffling and mixing, resulting in a varied combination before being passed on.


A few exceptions influence how DNA is passed down. Certain genes are exclusively inherited from the mother by all her children, while other exceptions relate to sex chromosomes. Let’s examine these exceptions to the rules more closely.


Mitochondria are present in nearly every human cell. They play a crucial role in generating energy to fuel cellular activities and essentially all of our biological processes. While the majority of DNA resides in chromosomes within the nucleus, mitochondria possess a small amount of their own genetic material, referred to as mitochondrial DNA.

Mitochondrial DNA does not play by the classic rules. Everyone strictly inherits their 37 Mitochondrial genes from their mother. This means we actually receive more DNA from our maternal grandmother than any other grandparent.

Gender Chromosomes

Sex chromosomes represent another deviation from the norm. Y chromosomes and X chromosomes are inherited from specific grandparents.

Only males carry Y chromosomes, and they are solely inherited from their fathers. Consequently, Y chromosomes are passed down through generations via the male lineage. Therefore, males will inherit the same Y chromosomes as their paternal grandfather.

For males, X chromosomes are not inherited from their fathers; they are solely received from their mothers. Consequently, males will only share X chromosomes with their maternal grandparents.

In contrast, females inherit X chromosomes from both their mothers and fathers. Thus, females could potentially match with either their maternal grandmother or their maternal grandfather. Furthermore, females will always have a match with their paternal grandmother.

Our Results

Let’s delve into the percentages. The chart provided offers a visual representation of how only the autosomal DNA was inherited. For clarity, we assigned a distinct color to each of the four grandparents and depicted how my parents inherited 50% from their respective parents. Below our parents, it displays how my sister and I received our DNA, indicating the percentages corresponding to each grandparent’s color.grandparent to grandchild dna passing process

Both my sister and I inherited DNA from each of our grandparents. However, our DNA shares from each grandparent were not always identical, nor were the amounts consistent across all grandparents.

It was no surprise that the DNA distribution between myself and my grandparents would differ from that of my sister and our grandparents. Nevertheless, we both inherited the largest portion from our paternal grandfather, which I found intriguing. It seems he possesses some particularly strong genes.

Given that we inherit 50% of our autosomal DNA from our mother, and based on my 21% match with my maternal grandmother after testing, we can reasonably assume that the remaining 29% of my DNA originates from my maternal grandfather.

I found the results from my paternal grandparents’ DNA rather surprising. Despite being told throughout my life that I resemble my paternal grandmother, it turns out I share the least amount of DNA with her. Surprisingly, I only matched with her at 16%, whereas I matched with my paternal grandfather at 34%. It seems appearances can be misleading.

So, How Much DNA do Grandparents and Grandchildren Share?

Certain segments of DNA are not inherited from specific grandparents. However, these segments constitute only a small fraction of everyone’s overall genetic makeup.

While the average amount of DNA in autosomal markers received from each grandparent is typically 25%, it’s evident from the data that the percentage can vary significantly from one grandchild to another.